COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-03058-0004-0000-2
Chemical Name: cis-1,2-Dichloroethylene
CASRN: 156-59-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 099212_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 04/22/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: cis-1,2-Dichloroethylene
500         
200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
1000         
200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
1600         
200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Positive Control: Mitomycin-C
 0.0625    
200 34 0.170 13.0 23 0.115 9.5 11 0.055 5.0 0 0.000 0.0
Mitomycin-C
 0.25      
50 20 0.400 36.0 8 0.160 16.0 12 0.240 24.0 0 0.000 0.0
Trend: 0.411 0.375 0.251  
Probability: 0.340 0.354 0.401  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/29/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: cis-1,2-Dichloroethylene
1600         
200 6 0.030 2.5 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0
3000         
200 11 0.055 3.0 5 0.025 1.5 6 0.030 2.0 0 0.000 0.0
5000         
200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide
2.5       
200 34 0.170 14.5 10 0.050 5.0 24 0.120 10.5 0 0.000 0.0
Cyclophosphamide
7.5       
50 21 0.420 36.0 9 0.180 16.0 12 0.240 22.0 0 0.000 0.0
Trend: 0.169 0.535 -0.105  
Probability: 0.433 0.296 0.542