Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03058-0004-0000-2 |
Chemical Name: | cis-1,2-Dichloroethylene |
CASRN: | 156-59-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 099212_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | cis-1,2-Dichloroethylene | 500 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
1000 | 200 | 3 | 0.015 | 1.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
1600 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 34 | 0.170 | 13.0 | 23 | 0.115 | 9.5 | 11 | 0.055 | 5.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 20 | 0.400 | 36.0 | 8 | 0.160 | 16.0 | 12 | 0.240 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.411 | 0.375 | 0.251 | ||||||||||||
Probability: | 0.340 | 0.354 | 0.401 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | cis-1,2-Dichloroethylene | 1600 | 200 | 6 | 0.030 | 2.5 | 1 | 0.005 | 0.5 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 |
3000 | 200 | 11 | 0.055 | 3.0 | 5 | 0.025 | 1.5 | 6 | 0.030 | 2.0 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 34 | 0.170 | 14.5 | 10 | 0.050 | 5.0 | 24 | 0.120 | 10.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 21 | 0.420 | 36.0 | 9 | 0.180 | 16.0 | 12 | 0.240 | 22.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.169 | 0.535 | -0.105 | ||||||||||||
Probability: | 0.433 | 0.296 | 0.542 |