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Study Information
Study Attribute Value
CEBS Accession Number: 002-03058-0005-0000-3
Chemical Name: trans-1,2-Dichloroethylene
CASRN: 156-60-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 894098_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 02/03/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 428 0.408 8.56 26.0 0.000
Test Chemical trans-1,2-Dichloroethylene 
160         
 50 1042 460 0.441 9.20 26.0 8.199 
500         
 50 1039 459 0.442 9.18 26.0 8.275 
1600         
 50 1039 474 0.456 9.48 26.0 11.814 
5000         
 50 1044 416 0.398 8.32 26.0 -2.338
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 561 0.535 11.22 26.0 31.075
Mitomycin-C 
 0.005     
 10 210 297 1.414 29.70 26.0 246.632
Trend: -0.064        
Probability: 0.526        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/28/1987    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 388 0.370 7.76 26.0 0.000
Test Chemical trans-1,2-Dichloroethylene 
160         
 50 1049 414 0.395 8.28 26.0 6.803 
500         
 50 1050 451 0.430 9.02 26.0 16.237 
1600         
 50 1050 457 0.435 9.14 26.0 17.784 
5000         
 50 1048 453 0.432 9.06 26.0 16.975
Positive Control Cyclophosphamide 
 0.1       
 50 1050 537 0.511 10.74 26.0 38.402
Cyclophosphamide 
 0.6       
 10 210 226 1.076 22.60 26.0 191.237
Trend: 2.648        
Probability: 0.004