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Study Information
Study Attribute Value
CEBS Accession Number: 002-03059-0001-0000-0
Chemical Name: cis-Dichlorodiamine platinum
CASRN: 15663-27-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 593235_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 05/29/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 491 0.468 9.82 26.5 0.000
Test Chemical cis-Dichlorodiamine platinum 
 0.16      
 10 210 289 1.376 28.90 26.5 194.297 
 0.5       
 10 210 525 2.500 52.50 26.5 434.623 
1.6       
 5 105 567 5.400 113.40 26.5 1054.786 
5         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 574 0.547 11.48 26.5 17.016
Mitomycin-C 
 0.005     
 10 210 329 1.567 32.90 26.5 235.031
Trend: 46.564        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/02/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 527 0.504 10.54 26.0 0.000
Test Chemical cis-Dichlorodiamine platinum 
 0.16      
 10 210 504 2.400 50.40 26.0 376.357 
 0.5       
 10 210 714 3.400 71.40 26.0 574.839 
1.6       
 4 84 469 5.583 117.25 26.0 1008.191 
5         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1045 600 0.574 12.00 26.0 13.961
Mitomycin-C 
 0.005     
 10 211 333 1.578 33.30 26.0 213.244
Trend: 48.187        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/29/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 518 0.495 10.36 26.0 0.000
Test Chemical cis-Dichlorodiamine platinum 
 0.5       
 50 1053 1075 1.021 21.50 26.0 106.149 
1.6       
 10 210 338 1.610 33.80 26.0 225.012 
5         
 10 211 702 3.327 70.20 26.0 571.826 
16         
 10 207 1116 5.391 111.60 26.0 988.669 
50         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.1       
 50 1046 629 0.601 12.58 26.0 21.429
Cyclophosphamide 
 0.6       
 10 209 274 1.311 27.40 26.0 164.732
Trend: 58.203        
Probability: 0.000