COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-03059-0002-0000-1
Chemical Name: cis-Dichlorodiamine platinum
CASRN: 15663-27-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 593235_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 07/16/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: cis-Dichlorodiamine platinum 
5         
 100 82 0.820 58.0 21 0.210 18.0 61 0.610 48.0 0 0.000 0.0 
10         
 100 121 1.210 67.0 41 0.410 31.0 80 0.800 57.0 0 0.000 0.0 
16         
 100 220 2.200 73.0 79 0.790 47.0 100 1.000 56.0 41 0.410 5.0 
30         
 100 141 1.410 59.0 30 0.300 27.0 81 0.810 46.0 30 0.300 3.0
Positive Control: Mitomycin-C 
 0.0625    
 200 30 0.150 13.0 8 0.040 4.0 22 0.110 9.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 27 0.540 34.0 14 0.280 22.0 13 0.260 26.0 0 0.000 0.0
Trend: 11.935 8.295 9.666  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/16/1986    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: cis-Dichlorodiamine platinum 
50         
 100 275 2.750 91.0 112 1.120 67.0 113 1.130 68.0 50 0.500 5.0 
100         
 100 397 3.970 84.0 65 0.650 37.0 121 1.210 57.0 211 2.110 22.0 
160         
 100 163 1.630 54.0 19 0.190 15.0 74 0.740 43.0 70 0.700 7.0 
500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 36 0.180 16.5 5 0.025 2.5 31 0.155 14.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 11 0.220 22.0 5 0.100 10.0 6 0.120 12.0 0 0.000 0.0
Trend: 12.239 4.813 9.522  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 08/19/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 7 0.035 3.5 1 0.005 0.5 6 0.030 3.0 0 0.000 0.0
Test Chemical: cis-Dichlorodiamine platinum 
5         
 25 32 1.280 64.0 11 0.440 28.0 21 0.840 56.0 0 0.000 0.0 
10         
 25 81 3.240 96.0 21 0.840 56.0 30 1.200 64.0 30 1.200 3.0 
16         
 25 73 2.920 72.0 11 0.440 36.0 22 0.880 48.0 40 1.600 4.0 
30         
 25 27 1.080 48.0 1 0.040 4.0 15 0.600 36.0 11 0.440 2.0
Positive Control: Mitomycin-C 
 0.125     
 200 35 0.175 16.5 19 0.095 9.0 16 0.080 8.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 17 0.340 28.0 3 0.060 6.0 14 0.280 24.0 0 0.000 0.0
Trend: 10.194 5.659 7.846  
Probability: 0.000 0.000 0.000