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Study Information
Study Attribute Value
CEBS Accession Number: 002-03063-0001-0000-5
Chemical Name: gamma-Butyrolactone
CASRN: 96-48-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 516280_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/24/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1045 464 0.444 9.28 26.5 0.000
Test Chemical gamma-Butyrolactone 
148         
 50 1040 528 0.508 10.56 26.5 14.340 
494         
 50 1040 439 0.422 8.78 26.5 -4.933 
1480         
 50 1045 515 0.493 10.30 26.5 10.991
Positive Control Mitomycin-C 
 0.002     
 50 1043 841 0.806 16.82 26.5 81.598
Mitomycin-C 
 0.01      
 10 208 350 1.683 35.00 26.5 278.968
Trend: 0.601        
Probability: 0.274        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/24/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1043 478 0.458 9.56 26.0 0.000
Test Chemical gamma-Butyrolactone 
494         
 50 1043 484 0.464 9.68 26.0 1.255 
1480         
 50 1046 509 0.487 10.18 26.0 6.180 
4940         
 50 1039 797 0.767 15.94 26.0 67.378
Positive Control Cyclophosphamide 
 0.5       
 50 1046 684 0.654 13.68 26.0 42.686
Cyclophosphamide 
2.5       
 10 209 307 1.469 30.70 26.0 220.515
Trend: 9.369        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/21/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1027 470 0.458 9.40 26.0 0.000
Test Chemical gamma-Butyrolactone 
3010         
 50 1041 693 0.666 13.86 26.0 45.464 
4010         
 100 2076 1401 0.675 14.01 26.0 47.463 
5010         
 50 1033 932 0.902 18.64 30.0 97.146
Positive Control Cyclophosphamide 
 0.5       
 50 1043 852 0.817 17.04 26.0 78.496
Cyclophosphamide 
2.5       
 10 210 400 1.905 40.00 26.0 316.211
Trend: 11.253        
Probability: 0.000