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Study Information
Study Attribute Value
CEBS Accession Number: 002-03063-0002-0000-6
Chemical Name: gamma-Butyrolactone
CASRN: 96-48-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 516280_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 08/30/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: gamma-Butyrolactone 
500         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
1500         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
4990         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
5         
 100 31 0.310 22.0 20 0.200 16.0 11 0.110 8.0 0 0.000 0.0
Trend: -0.148 -0.440 0.000  
Probability: 0.559 0.670 0.500  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/13/1984    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: gamma-Butyrolactone 
2210         
 100 4 0.040 3.0 0 0.000 0.0 4 0.040 3.0 0 0.000 0.0 
2580         
 100 7 0.070 7.0 1 0.010 1.0 6 0.060 6.0 0 0.000 0.0 
2950         
 100 83 0.830 58.0 7 0.070 6.0 56 0.560 53.0 20 0.200 2.0
Positive Control: Cyclophosphamide 
50         
 100 58 0.580 37.0 32 0.320 26.0 24 0.240 21.0 2 0.020 2.0
Trend: 10.432 3.197 9.850  
Probability: 0.000 0.001 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 08/30/1984    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: gamma-Butyrolactone 
400         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1200         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1500         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
2990         
 100 84 0.840 61.0 28 0.280 24.0 56 0.560 51.0 0 0.000 0.0 
3990         
 93 87 0.935 78.0 0 0.000 0.0 77 0.828 77.0 10 0.108 1.0
Positive Control: Cyclophosphamide 
50         
 100 79 0.790 41.0 41 0.410 34.0 18 0.180 15.0 20 0.200 2.0
Trend: 14.663 4.865 14.016  
Probability: 0.000 0.000 0.000