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Study Information
Study Attribute Value
CEBS Accession Number: 002-03065-0001-0000-7
Chemical Name: m-Anisidine
CASRN: 536-90-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 584493_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 12/01/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 427 0.407 8.54 26.0 0.000
Test Chemical m-Anisidine 
50         
 100 2099 1053 0.502 10.53 26.0 23.361 
160         
 50 1048 529 0.505 10.58 26.0 24.124 
500         
 50 1050 621 0.591 12.42 26.0 45.433
Positive Control Mitomycin-C 
 0.005     
 25 526 740 1.407 29.60 26.0 245.945
Trend: 5.584        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/07/1982    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 492 0.469 9.84 26.0 0.000
Test Chemical m-Anisidine 
160         
 50 1046 460 0.440 9.20 26.0 -6.325 
500         
 50 1044 493 0.472 9.86 26.0 0.587 
1600         
 50 1042 565 0.542 11.30 26.0 15.499 
5000         
 25 520 292 0.562 11.68 28.0 19.612
Positive Control Cyclophosphamide 
1         
 25 522 513 0.983 20.52 26.0 109.336
Trend: 3.559        
Probability: 0.000