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Study Information
Study Attribute Value
CEBS Accession Number: 002-03067-0001-0000-9
Chemical Name: m-Chloroaniline
CASRN: 108-42-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 943184_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 03/01/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 473 0.455 9.46 25.5 0.000
Test Chemical m-Chloroaniline 
80         
 50 1017 580 0.570 11.60 32.8 25.274 
89.4       
 50 1029 632 0.614 12.64 32.8 34.914 
100         
 50 1031 651 0.631 13.02 32.8 38.700 
124         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1024 673 0.657 13.46 25.5 44.368
Mitomycin-C 
 0.01      
 5 99 236 2.384 47.20 25.5 423.638
Trend: 5.601        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/16/1983    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1027 457 0.445 9.14 25.5 0.000
Test Chemical m-Chloroaniline 
111         
 50 1019 422 0.414 8.44 25.5 -6.934 
370         
 50 1036 479 0.462 9.58 25.5 3.903 
1100         
 50 1026 540 0.526 10.80 25.5 18.277 
3700         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1034 631 0.610 12.62 25.5 37.140
Cyclophosphamide 
2         
 5 102 135 1.324 27.00 25.5 197.432
Trend: 3.049        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/09/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1018 491 0.482 9.82 25.5 0.000
Test Chemical m-Chloroaniline 
198         
 50 1027 523 0.509 10.46 25.5 5.584 
402         
 50 1023 554 0.542 11.08 25.5 12.279 
600         
 50 1020 617 0.605 12.34 25.5 25.416 
804         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1029 616 0.599 12.32 25.5 24.117
Cyclophosphamide 
2         
 5 104 132 1.269 26.40 25.5 163.152
Trend: 3.839        
Probability: 0.000