Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-03067-0002-0000-0
Chemical Name: m-Chloroaniline
CASRN: 108-42-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 943184_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 03/10/1983    Harvest Time: 20.8 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: m-Chloroaniline 
252.1       
 100 5 0.050 4.0 0 0.000 0.0 3 0.030 2.0 2 0.020 2.0 
300.2       
 100 13 0.130 12.0 5 0.050 5.0 3 0.030 3.0 5 0.050 5.0 
400.3       
 100 13 0.130 11.0 5 0.050 5.0 4 0.040 4.0 4 0.040 4.0
Positive Control: Mitomycin-C 
 0.0625    
 50 14 0.280 26.0 9 0.180 18.0 5 0.100 8.0 0 0.000 0.0
Trend: 3.496 2.745 1.944  
Probability: 0.000 0.003 0.026  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/15/1983    Harvest Time: 10.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 2.0 0 0.000 0.0 2 0.020 1.0 1 0.010 1.0
Test Chemical: m-Chloroaniline 
397.7       
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
497.1       
 100 10 0.100 6.0 5 0.050 4.0 2 0.020 1.0 3 0.030 3.0 
598.9       
 100 32 0.320 19.0 11 0.110 10.0 20 0.200 12.0 1 0.010 1.0 
679.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 13 0.130 13.0 4 0.040 4.0 5 0.050 5.0 4 0.040 4.0
Trend: 4.573 3.639 3.853  
Probability: 0.000 0.000 0.000