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Study Information
Study Attribute Value
CEBS Accession Number: 002-03067-0002-0000-0
Chemical Name: m-Chloroaniline
CASRN: 108-42-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 943184_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 03/10/1983    Harvest Time: 20.8 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: m-Chloroaniline 
252.1       
 100 5 0.050 4.0 0 0.000 0.0 3 0.030 2.0 2 0.020 2.0 
300.2       
 100 13 0.130 12.0 5 0.050 5.0 3 0.030 3.0 5 0.050 5.0 
400.3       
 100 13 0.130 11.0 5 0.050 5.0 4 0.040 4.0 4 0.040 4.0
Positive Control: Mitomycin-C 
 0.0625    
 50 14 0.280 26.0 9 0.180 18.0 5 0.100 8.0 0 0.000 0.0
Trend: 3.496 2.745 1.944  
Probability: 0.000 0.003 0.026  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/15/1983    Harvest Time: 10.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 2.0 0 0.000 0.0 2 0.020 1.0 1 0.010 1.0
Test Chemical: m-Chloroaniline 
397.7       
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
497.1       
 100 10 0.100 6.0 5 0.050 4.0 2 0.020 1.0 3 0.030 3.0 
598.9       
 100 32 0.320 19.0 11 0.110 10.0 20 0.200 12.0 1 0.010 1.0 
679.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 13 0.130 13.0 4 0.040 4.0 5 0.050 5.0 4 0.040 4.0
Trend: 4.573 3.639 3.853  
Probability: 0.000 0.000 0.000