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Study Information
Study Attribute Value
CEBS Accession Number: 002-03070-0001-0000-3
Chemical Name: m-Chloronitrobenzene
CASRN: 121-73-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 441275_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/09/1981    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 430 0.410 8.60 26.0 0.000
Test Chemical m-Chloronitrobenzene 
5         
 50 1051 439 0.418 8.78 26.0 1.899 
16         
 50 1049 505 0.481 10.10 26.0 17.442 
50         
 50 1048 501 0.478 10.02 26.0 16.623
Positive Control Mitomycin-C 
 0.005     
 25 524 669 1.277 26.76 26.0 211.460
Triethylenemelamine 
 0.015     
 25 524 820 1.565 32.80 26.0 281.759
Trend: 2.910        
Probability: 0.002        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/09/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 501 0.479 10.02 26.0 0.000
Test Chemical m-Chloronitrobenzene 
1.6       
 50 1051 493 0.469 9.86 26.0 -1.971 
5         
 50 1048 471 0.449 9.42 26.0 -6.078 
160         
 50 1051 446 0.424 8.92 26.0 -11.317
Positive Control Cyclophosphamide 
1         
 25 528 481 0.911 19.24 26.0 90.379
Trend: -1.953        
Probability: 0.975