Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03070-0002-0000-4 |
Chemical Name: | m-Chloronitrobenzene |
CASRN: | 121-73-3 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 441275_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | m-Chloronitrobenzene | 50 | 100 | 5 | 0.050 | 5.0 | 2 | 0.020 | 2.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
160 | 100 | 5 | 0.050 | 5.0 | 2 | 0.020 | 2.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
500 | 100 | 8 | 0.080 | 8.0 | 1 | 0.010 | 1.0 | 7 | 0.070 | 7.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 100 | 19 | 0.190 | 17.0 | 10 | 0.100 | 10.0 | 9 | 0.090 | 7.0 | 0 | 0.000 | 0.0 |
Triethylenemelamine | 0.15 | 100 | 28 | 0.280 | 25.0 | 5 | 0.050 | 5.0 | 23 | 0.230 | 21.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.502 | 0.606 | 1.366 | ||||||||||||
Probability: | 0.067 | 0.272 | 0.086 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | m-Chloronitrobenzene | 50 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
160 | 100 | 5 | 0.050 | 4.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 | ||
500 | 100 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 33 | 0.330 | 27.0 | 13 | 0.130 | 11.0 | 20 | 0.200 | 17.0 | 0 | 0.000 | 0.0 |
Trend: | 0.684 | 0.454 | 0.586 | ||||||||||||
Probability: | 0.247 | 0.325 | 0.279 |