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Study Information
Study Attribute Value
CEBS Accession Number: 002-03072-0001-0000-5
Chemical Name: m-Cresidine
CASRN: 102-50-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 665516_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/30/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 395 0.380 7.90 26.0 0.000
Test Chemical m-Cresidine 
1.6       
 50 1044 471 0.451 9.42 26.0 18.784 
5         
 50 1039 450 0.433 9.00 26.0 14.034 
16         
 50 1041 512 0.492 10.24 26.0 29.496 
50         
 50 1046 647 0.619 12.94 26.0 62.858 
160         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1047 556 0.531 11.12 26.0 39.818
Mitomycin-C 
 0.005     
 10 210 292 1.390 29.20 26.0 266.100
Trend: 7.682        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/24/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 458 0.437 9.16 26.0 0.000
Test Chemical m-Cresidine 
5         
 50 1049 506 0.482 10.12 26.0 10.480 
16         
 50 1043 530 0.508 10.60 26.0 16.386 
50         
 50 1044 602 0.577 12.04 26.0 32.071 
100         
 50 1049 714 0.681 14.28 31.0 55.895 
160         
 27 567 533 0.940 19.74 31.0 115.305
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 562 0.535 11.24 26.0 22.591
Mitomycin-C 
 0.005     
 10 210 273 1.300 27.30 28.0 197.751
Trend: 12.367        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/30/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 409 0.390 8.18 26.0 0.000
Test Chemical m-Cresidine 
16         
 50 1046 418 0.400 8.36 26.0 2.396 
50         
 50 1047 435 0.415 8.70 26.0 6.459 
160         
 50 1049 451 0.430 9.02 26.0 10.164 
500         
 50 1044 569 0.545 11.38 26.0 39.653 
1600         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.1       
 50 1043 558 0.535 11.16 26.0 37.084
Cyclophosphamide 
 0.6       
 10 209 198 0.947 19.80 26.0 142.749
Trend: 5.255        
Probability: 0.000