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Study Information
Study Attribute Value
CEBS Accession Number: 002-03072-0002-0000-6
Chemical Name: m-Cresidine
CASRN: 102-50-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 665516_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 03/12/1987    Harvest Time: 12 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: m-Cresidine 
160         
 200 9 0.045 4.5 1 0.005 0.5 8 0.040 4.0 0 0.000 0.0 
300         
 200 9 0.045 3.5 3 0.015 1.5 6 0.030 3.0 0 0.000 0.0 
500         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 45 0.225 20.0 13 0.065 6.5 32 0.160 14.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 19 0.380 34.0 4 0.080 8.0 15 0.300 28.0 0 0.000 0.0
Trend: -0.156 0.535 -0.177  
Probability: 0.562 0.296 0.570  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/29/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: m-Cresidine 
300         
 200 6 0.030 1.5 2 0.010 0.5 4 0.020 1.0 0 0.000 0.0 
500         
 200 20 0.100 5.0 8 0.040 2.5 12 0.060 4.0 0 0.000 0.0 
1000         
 200 62 0.310 17.0 29 0.145 11.5 22 0.110 7.0 11 0.055 2.0
Positive Control: Cyclophosphamide 
31         
 200 35 0.175 15.0 8 0.040 4.0 27 0.135 11.5 0 0.000 0.0
Cyclophosphamide 
31         
 50 33 0.660 36.0 9 0.180 12.0 24 0.480 32.0 0 0.000 0.0
Trend: 6.930 6.318 3.755  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 03/29/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: m-Cresidine 
300         
 200 6 0.030 1.5 2 0.010 0.5 4 0.020 1.0 0 0.000 0.0 
500         
 200 20 0.100 5.0 8 0.040 2.5 12 0.060 4.0 0 0.000 0.0 
1000         
 200 62 0.310 17.0 29 0.145 11.5 22 0.110 7.0 11 0.055 2.0 
1600         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 35 0.175 15.0 8 0.040 4.0 27 0.135 11.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 33 0.660 36.0 9 0.180 12.0 24 0.480 32.0 0 0.000 0.0
Trend: 6.982 6.366 3.778  
Probability: 0.000 0.000 0.000