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Study Information
Study Attribute Value
CEBS Accession Number: 002-03078-0001-0000-1
Chemical Name: m-Nitrobenzoic acid
CASRN: 121-92-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 013799_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/13/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 446 0.434 8.92 25.5 0.000
Test Chemical m-Nitrobenzoic acid 
50         
 50 1027 385 0.375 7.70 25.5 -13.593 
166.7       
 50 1014 411 0.405 8.22 25.5 -6.575 
500         
 50 1014 422 0.416 8.44 25.5 -4.075 
1700         
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1016 537 0.529 10.74 25.5 21.826
Mitomycin-C 
 0.01      
 5 105 205 1.952 41.00 25.5 350.011
Trend: -0.270        
Probability: 0.607        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/13/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 459 0.445 9.18 25.5 0.000
Test Chemical m-Nitrobenzoic acid 
166.7       
 50 1024 462 0.451 9.24 25.5 1.342 
500         
 50 1020 485 0.475 9.70 25.5 6.804 
1666.7       
 50 1034 481 0.465 9.62 25.5 4.489 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1020 697 0.683 13.94 25.5 53.489
Cyclophosphamide 
2         
 5 103 217 2.107 43.40 25.5 373.226
Trend: 0.878        
Probability: 0.190