Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03078-0002-0000-2 |
Chemical Name: | m-Nitrobenzoic acid |
CASRN: | 121-92-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 013799_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | m-Nitrobenzoic acid | 1500 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
2500 | 100 | 5 | 0.050 | 4.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 1.0 | ||
3000 | 100 | 7 | 0.070 | 6.0 | 2 | 0.020 | 2.0 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | ||
4000 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.5 | 100 | 14 | 0.140 | 14.0 | 4 | 0.040 | 4.0 | 10 | 0.100 | 10.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 1 | 25 | 10 | 0.400 | 28.0 | 4 | 0.160 | 16.0 | 6 | 0.240 | 16.0 | 0 | 0.000 | 0.0 | |
Trend: | 2.106 | 1.458 | 1.339 | ||||||||||||
Probability: | 0.018 | 0.072 | 0.090 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | m-Nitrobenzoic acid | 2000 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
2500 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
3000 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
4000 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 100 | 7 | 0.070 | 7.0 | 1 | 0.010 | 1.0 | 6 | 0.060 | 6.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 37.5 | 25 | 20 | 0.800 | 48.0 | 10 | 0.400 | 32.0 | 9 | 0.360 | 28.0 | 1 | 0.040 | 4.0 | |
Trend: | -0.198 | -0.743 | 0.384 | ||||||||||||
Probability: | 0.578 | 0.771 | 0.351 |