Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03083-0002-0000-8 |
Chemical Name: | m-Phenylenediamine |
CASRN: | 108-45-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 434853_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
No Activation | 2 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 4 | 0.020 | 1.5 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | m-Phenylenediamine | 246.5 | 100 | 75 | 0.750 | 31.0 | 9 | 0.090 | 5.0 | 46 | 0.460 | 28.0 | 20 | 0.200 | 2.0 |
502.5 | 100 | 85 | 0.850 | 32.0 | 12 | 0.120 | 11.0 | 43 | 0.430 | 24.0 | 30 | 0.300 | 3.0 | ||
747 | 25 | 50 | 2.000 | 64.0 | 6 | 0.240 | 12.0 | 24 | 0.960 | 52.0 | 20 | 0.800 | 8.0 | ||
1000 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 200 | 63 | 0.315 | 19.5 | 22 | 0.110 | 9.5 | 41 | 0.205 | 14.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 46 | 1.840 | 64.0 | 6 | 0.240 | 20.0 | 30 | 1.200 | 56.0 | 10 | 0.400 | 4.0 | |
Trend: | 8.627 | 4.406 | 7.128 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 6 | 0.030 | 2.5 | 0 | 0.000 | 0.0 | 6 | 0.030 | 2.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 5 | 0.025 | 2.5 | 2 | 0.010 | 1.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | m-Phenylenediamine | 2513 | 200 | 13 | 0.065 | 4.5 | 5 | 0.025 | 2.5 | 8 | 0.040 | 2.5 | 0 | 0.000 | 0.0 |
3750 | 200 | 7 | 0.035 | 2.5 | 2 | 0.010 | 1.0 | 5 | 0.025 | 2.0 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 15 | 0.075 | 6.0 | 7 | 0.035 | 3.5 | 8 | 0.040 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 200 | 17 | 0.085 | 7.0 | 3 | 0.015 | 1.5 | 14 | 0.070 | 5.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 37.5 | 25 | 9 | 0.360 | 28.0 | 4 | 0.160 | 12.0 | 5 | 0.200 | 16.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.295 | 1.258 | 0.821 | ||||||||||||
Probability: | 0.098 | 0.104 | 0.206 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | m-Phenylenediamine | 251.3 | 100 | 56 | 0.560 | 23.0 | 6 | 0.060 | 6.0 | 20 | 0.200 | 16.0 | 30 | 0.300 | 3.0 |
502.5 | 25 | 39 | 1.560 | 44.0 | 6 | 0.240 | 16.0 | 23 | 0.920 | 40.0 | 10 | 0.400 | 4.0 | ||
750 | 50 | 58 | 1.160 | 48.0 | 10 | 0.200 | 14.0 | 38 | 0.760 | 40.0 | 10 | 0.200 | 2.0 | ||
1000 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 100 | 41 | 0.410 | 30.0 | 16 | 0.160 | 14.0 | 25 | 0.250 | 19.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 30 | 1.200 | 52.0 | 10 | 0.400 | 28.0 | 20 | 0.800 | 40.0 | 0 | 0.000 | 0.0 | |
Trend: | 6.761 | 3.850 | 6.260 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |