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Study Information
Study Attribute Value
CEBS Accession Number: 002-03090-0001-0000-5
Chemical Name: n-Butyl acrylate
CASRN: 141-32-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 679128_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/04/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 463 0.441 9.26 26.0 0.000
Test Chemical n-Butyl acrylate 
1.7       
 50 1050 490 0.467 9.80 26.0 5.731 
5         
 50 1048 472 0.450 9.44 26.0 2.041 
16.8       
 50 1043 733 0.703 14.66 32.0 59.226 
50.3       
 0 0 0 0.000 0.00 32.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1040 590 0.567 11.80 26.0 28.533
Mitomycin-C 
 0.01      
 5 105 221 2.105 44.20 26.0 376.867
Trend: 7.860        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/15/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 524 208 0.397 8.32 25.8 0.000
Test Chemical n-Butyl acrylate 
5.1       
 25 513 354 0.690 14.16 25.8 73.842 
10.1       
 25 520 487 0.937 19.48 31.5 135.936 
16.8       
 0 0 0 0.000 0.00 31.5 N/A
Positive Control Mitomycin-C 
 0.001     
 25 525 297 0.566 11.88 25.8 42.516
Mitomycin-C 
 0.01      
 5 103 173 1.680 34.60 25.8 323.133
Trend: 10.593        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/04/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 484 0.461 9.68 26.0 0.000
Test Chemical n-Butyl acrylate 
16.8       
 50 1039 490 0.472 9.80 26.0 2.214 
50.3       
 50 1043 488 0.468 9.76 26.0 1.406 
167.5       
 50 1049 587 0.560 11.74 26.0 21.281 
502.6       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1049 590 0.562 11.80 26.0 21.901
Cyclophosphamide 
2         
 5 105 84 0.800 16.80 26.0 73.388
Trend: 3.049        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/15/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 520 202 0.388 8.08 25.8 0.000
Test Chemical n-Butyl acrylate 
100         
 25 522 258 0.494 10.32 25.8 27.233 
166.7       
 25 518 307 0.593 12.28 25.8 52.567 
248.8       
 25 518 332 0.641 13.28 31.5 64.991 
377         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 25 522 307 0.588 12.28 25.8 51.398
Cyclophosphamide 
2         
 5 104 183 1.760 36.60 25.8 352.970
Trend: 6.020        
Probability: 0.000