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Study Information
Study Attribute Value
CEBS Accession Number: 002-03091-0002-0000-7
Chemical Name: n-Butyl chloride
CASRN: 109-69-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 297558_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 02/10/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: n-Butyl chloride 
160         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
500         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
1600         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
5000         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0
Positive Control: Mitomycin-C 
 0.25      
 100 37 0.370 27.0 15 0.150 14.0 22 0.220 16.0 0 0.000 0.0
Mitomycin-C 
1         
 50 24 0.480 44.0 6 0.120 12.0 18 0.360 32.0 0 0.000 0.0
Trend: -0.217 -0.322 -0.633  
Probability: 0.586 0.626 0.737  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/09/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 3.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: n-Butyl chloride 
160         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
500         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
1600         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
5000         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 27 0.270 19.0 17 0.170 13.0 10 0.100 8.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 19 0.380 28.0 12 0.240 16.0 7 0.140 14.0 0 0.000 0.0
Trend: -0.863 -0.409 -0.757  
Probability: 0.806 0.659 0.776  


Trial #:2   Activation: No Activation    Date: 03/29/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: n-Butyl chloride 
1600         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
3000         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
4000         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
5000         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 21 0.210 16.0 11 0.110 10.0 10 0.100 9.0 0 0.000 0.0
Mitomycin-C 
1         
 50 24 0.480 38.0 11 0.220 20.0 13 0.260 20.0 0 0.000 0.0
Trend: 0.225 0.802 -0.087  
Probability: 0.411 0.211 0.535  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 03/29/1984    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 2.0 3 0.030 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 3.0 1 0.010 1.0 4 0.040 2.0 0 0.000 0.0
Test Chemical: n-Butyl chloride 
1600         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
3000         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0 
4000         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
5000         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 56 0.560 42.0 32 0.320 27.0 24 0.240 23.0 0 0.000 0.0
Cyclophosphamide 
50         
 100 87 0.870 51.0 32 0.320 26.0 55 0.550 39.0 0 0.000 0.0
Trend: -0.024 -0.480 0.172  
Probability: 0.509 0.685 0.432