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Study Information
Study Attribute Value
CEBS Accession Number: 002-03100-0001-0000-7
Chemical Name: n-Hexane
CASRN: 110-54-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 587411_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/13/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1049 290 0.276 5.80 25.6 0.000
Test Chemical n-Hexane 
16.7       
 50 1043 315 0.302 6.30 25.6 9.246 
50.2       
 50 1045 323 0.309 6.46 25.6 11.806 
5000         
 50 1050 335 0.319 6.70 25.6 15.407
Positive Control Mitomycin-C 
 0.001     
 50 1049 633 0.603 12.66 25.6 118.276
Mitomycin-C 
 0.01      
 5 106 190 1.792 38.00 25.6 548.373
Trend: 1.716        
Probability: 0.043        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/13/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1049 402 0.383 8.04 25.6 0.000
Test Chemical n-Hexane 
16.7       
 50 1043 581 0.557 11.62 25.6 45.359 
50.2       
 50 1046 581 0.555 11.62 25.6 44.942 
5000         
 50 1049 575 0.548 11.50 25.6 43.035
Positive Control Cyclophosphamide 
 0.4       
 50 1046 637 0.609 12.74 25.6 58.912
Cyclophosphamide 
2         
 5 104 186 1.788 37.20 25.6 366.691
Trend: 4.601        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/05/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 25 523 148 0.283 5.92 25.5 0.000
Test Chemical n-Hexane 
126         
 25 522 252 0.483 10.08 25.5 70.596 
2509         
 25 524 232 0.443 9.28 25.5 56.458 
5000         
 25 521 235 0.451 9.40 25.5 59.393
Positive Control Cyclophosphamide 
 0.4       
 25 523 347 0.663 13.88 25.5 134.459
Cyclophosphamide 
2         
 5 104 170 1.635 34.00 25.5 477.638
Trend: 3.643        
Probability: 0.000