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Study Information
Study Attribute Value
CEBS Accession Number: 002-03100-0002-0000-8
Chemical Name: n-Hexane
CASRN: 110-54-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 587411_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 02/26/1987    Harvest Time: 10.1 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Ethanol 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: n-Hexane 
50         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
2500         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
5000         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 200 20 0.100 9.0 9 0.045 4.5 11 0.055 4.5 0 0.000 0.0
Mitomycin-C 
 0.75      
 25 16 0.640 40.0 4 0.160 16.0 12 0.480 36.0 0 0.000 0.0
Trend: 1.558 1.221 0.992  
Probability: 0.060 0.111 0.161  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/26/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Ethanol 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: n-Hexane 
50         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
1300         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
2500         
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0 
5000         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 28 0.140 13.0 12 0.060 6.0 16 0.080 7.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 17 0.680 44.0 7 0.280 24.0 10 0.400 28.0 0 0.000 0.0
Trend: -0.567 0.151 -0.697  
Probability: 0.715 0.440 0.757