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Study Information
Study Attribute Value
CEBS Accession Number: 002-03106-0001-0000-3
Chemical Name: o,p'-DDD
CASRN: 53-19-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 189721_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/26/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 465 0.445 9.30 26.0 0.000
Test Chemical o,p'-DDD 
1.6       
 50 1047 460 0.439 9.20 26.0 -1.359 
5         
 50 1047 438 0.418 8.76 26.0 -6.076 
16         
 50 1046 444 0.424 8.88 26.0 -4.699
Positive Control Mitomycin-C 
 0.005     
 25 524 603 1.151 24.12 26.0 158.365
Trend: -0.920        
Probability: 0.821        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/26/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 100 2094 1029 0.491 10.29 26.0 0.000
Test Chemical o,p'-DDD 
1.6       
 45 940 449 0.478 9.98 26.0 -2.797 
5         
 50 1045 512 0.490 10.24 26.0 -0.295 
16         
 50 1044 570 0.546 11.40 26.0 11.106
Positive Control Cyclophosphamide 
1         
 100 2094 1714 0.819 17.14 26.0 66.569
Trend: 1.746        
Probability: 0.040