Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03106-0001-0000-3 |
Chemical Name: | o,p'-DDD |
CASRN: | 53-19-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 189721_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1044 | 465 | 0.445 | 9.30 | 26.0 | 0.000 |
Test Chemical | o,p'-DDD | 1.6 | 50 | 1047 | 460 | 0.439 | 9.20 | 26.0 | -1.359 |
5 | 50 | 1047 | 438 | 0.418 | 8.76 | 26.0 | -6.076 | ||
16 | 50 | 1046 | 444 | 0.424 | 8.88 | 26.0 | -4.699 | ||
Positive Control | Mitomycin-C | 0.005 | 25 | 524 | 603 | 1.151 | 24.12 | 26.0 | 158.365 |
Trend: | -0.920 | ||||||||
Probability: | 0.821 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 100 | 2094 | 1029 | 0.491 | 10.29 | 26.0 | 0.000 |
Test Chemical | o,p'-DDD | 1.6 | 45 | 940 | 449 | 0.478 | 9.98 | 26.0 | -2.797 |
5 | 50 | 1045 | 512 | 0.490 | 10.24 | 26.0 | -0.295 | ||
16 | 50 | 1044 | 570 | 0.546 | 11.40 | 26.0 | 11.106 | ||
Positive Control | Cyclophosphamide | 1 | 100 | 2094 | 1714 | 0.819 | 17.14 | 26.0 | 66.569 |
Trend: | 1.746 | ||||||||
Probability: | 0.040 |