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Study Information
Study Attribute Value
CEBS Accession Number: 002-03106-0002-0000-4
Chemical Name: o,p'-DDD
CASRN: 53-19-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 189721_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/26/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: o,p'-DDD
1.6       
100 7 0.070 6.0 1 0.010 1.0 6 0.060 5.0 0 0.000 0.0
5         
100 6 0.060 5.0 4 0.040 3.0 2 0.020 2.0 0 0.000 0.0
16         
100 11 0.110 11.0 4 0.040 4.0 7 0.070 7.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.15      
100 41 0.410 27.0 12 0.120 12.0 29 0.290 20.0 0 0.000 0.0
Trend: 1.819 2.235 0.653  
Probability: 0.034 0.013 0.257  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/26/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0
Test Chemical: o,p'-DDD
1.6       
100 10 0.100 9.0 4 0.040 3.0 6 0.060 6.0 0 0.000 0.0
5         
100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0
16         
100 10 0.100 10.0 2 0.020 2.0 8 0.080 8.0 0 0.000 0.0
50         
100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide
15         
100 30 0.300 26.0 7 0.070 7.0 23 0.230 22.0 0 0.000 0.0
Trend: -0.121 0.252 -0.277  
Probability: 0.548 0.401 0.609