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Study Information
Study Attribute Value
CEBS Accession Number: 002-03106-0002-0000-4
Chemical Name: o,p'-DDD
CASRN: 53-19-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 189721_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/26/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: o,p'-DDD 
1.6       
 100 7 0.070 6.0 1 0.010 1.0 6 0.060 5.0 0 0.000 0.0 
5         
 100 6 0.060 5.0 4 0.040 3.0 2 0.020 2.0 0 0.000 0.0 
16         
 100 11 0.110 11.0 4 0.040 4.0 7 0.070 7.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 41 0.410 27.0 12 0.120 12.0 29 0.290 20.0 0 0.000 0.0
Trend: 1.819 2.235 0.653  
Probability: 0.034 0.013 0.257  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/26/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0
Test Chemical: o,p'-DDD 
1.6       
 100 10 0.100 9.0 4 0.040 3.0 6 0.060 6.0 0 0.000 0.0 
5         
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0 
16         
 100 10 0.100 10.0 2 0.020 2.0 8 0.080 8.0 0 0.000 0.0 
50         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 30 0.300 26.0 7 0.070 7.0 23 0.230 22.0 0 0.000 0.0
Trend: -0.121 0.252 -0.277  
Probability: 0.548 0.401 0.609