Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03106-0002-0000-4 |
Chemical Name: | o,p'-DDD |
CASRN: | 53-19-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 189721_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
Test Chemical: | o,p'-DDD | 1.6 | 100 | 7 | 0.070 | 6.0 | 1 | 0.010 | 1.0 | 6 | 0.060 | 5.0 | 0 | 0.000 | 0.0 |
5 | 100 | 6 | 0.060 | 5.0 | 4 | 0.040 | 3.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
16 | 100 | 11 | 0.110 | 11.0 | 4 | 0.040 | 4.0 | 7 | 0.070 | 7.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.15 | 100 | 41 | 0.410 | 27.0 | 12 | 0.120 | 12.0 | 29 | 0.290 | 20.0 | 0 | 0.000 | 0.0 |
Trend: | 1.819 | 2.235 | 0.653 | ||||||||||||
Probability: | 0.034 | 0.013 | 0.257 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 |
Test Chemical: | o,p'-DDD | 1.6 | 100 | 10 | 0.100 | 9.0 | 4 | 0.040 | 3.0 | 6 | 0.060 | 6.0 | 0 | 0.000 | 0.0 |
5 | 100 | 7 | 0.070 | 7.0 | 2 | 0.020 | 2.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | ||
16 | 100 | 10 | 0.100 | 10.0 | 2 | 0.020 | 2.0 | 8 | 0.080 | 8.0 | 0 | 0.000 | 0.0 | ||
50 | 100 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 30 | 0.300 | 26.0 | 7 | 0.070 | 7.0 | 23 | 0.230 | 22.0 | 0 | 0.000 | 0.0 |
Trend: | -0.121 | 0.252 | -0.277 | ||||||||||||
Probability: | 0.548 | 0.401 | 0.609 |