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Study Information
Study Attribute Value
CEBS Accession Number: 002-03109-0001-0000-6
Chemical Name: o-Anisidine
CASRN: 90-04-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 755244_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9   
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 08/11/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 448 0.430 8.96 26.0 0.000
Test Chemical o-Anisidine 
38         
 50 1049 556 0.530 11.12 26.0 23.279 
113         
 50 1042 629 0.604 12.58 26.0 40.402 
377         
 50 1032 759 0.735 15.18 26.0 71.061 
1100         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 25 519 559 1.077 22.36 26.0 150.515
Trend: 9.428        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/11/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 421 0.404 8.42 26.0 0.000
Test Chemical o-Anisidine 
1100         
 50 1042 507 0.487 10.14 26.0 20.312 
3800         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 25 525 533 1.015 21.32 26.0 151.036
Trend: 2.808        
Probability: 0.002        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/02/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 433 0.414 8.66 25.5 0.000
Test Chemical o-Anisidine 
2500         
 50 1048 664 0.634 13.28 25.5 53.056 
2750         
 50 1045 680 0.651 13.60 31.7 57.194 
3000         
 50 1037 802 0.773 16.04 31.7 86.827
Positive Control Cyclophosphamide 
 0.3       
 50 1045 656 0.628 13.12 25.5 51.646
o-Anisidine 
2         
 5 105 165 1.571 33.00 25.5 279.611
Trend: 10.042        
Probability: 0.000