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Study Information
Study Attribute Value
CEBS Accession Number: 002-03109-0002-0000-7
Chemical Name: o-Anisidine
CASRN: 90-04-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 755244_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 09/06/1982    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: o-Anisidine 
1200         
 100 13 0.130 12.0 2 0.020 2.0 11 0.110 11.0 0 0.000 0.0 
1300         
 100 7 0.070 7.0 3 0.030 3.0 2 0.020 2.0 2 0.020 2.0 
1400         
 50 10 0.200 6.0 1 0.020 2.0 9 0.180 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.065     
 50 14 0.280 20.0 6 0.120 12.0 8 0.160 10.0 0 0.000 0.0
Trend: -1.385 0.122 -1.706  
Probability: 0.917 0.451 0.956  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/06/1982    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: o-Anisidine 
2400         
 100 17 0.170 15.0 9 0.090 9.0 8 0.080 8.0 0 0.000 0.0 
2600         
 50 85 1.700 56.0 21 0.420 26.0 54 1.080 48.0 10 0.200 2.0 
2800         
 50 136 2.720 74.0 39 0.780 44.0 77 1.540 64.0 20 0.400 4.0 
3000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
10         
 50 20 0.400 20.0 9 0.180 16.0 1 0.020 2.0 10 0.200 2.0
Trend: 10.696 7.604 10.045  
Probability: 0.000 0.000 0.000