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Study Information
Study Attribute Value
CEBS Accession Number: 002-03110-0001-0000-8
Chemical Name: o-Anthranilic acid
CASRN: 118-92-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 313261_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Positive 
Induced Rat Liver S9  3_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/23/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 452 0.434 9.04 27.0 0.000
Negative (Not Specified) 
0         
 50 1025 369 0.360 7.38 27.0 -17.009
Test Chemical o-Anthranilic acid 
50         
 50 1027 444 0.432 8.88 27.0 -0.335 
160         
 50 990 414 0.418 8.28 27.0 -3.596 
500         
 50 1040 530 0.510 10.60 27.0 17.482 
1600         
 50 1027 650 0.633 13.00 27.0 45.906 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1004 2243 2.234 44.86 27.0 415.021
Trend: 6.915        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 10/06/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1042 403 0.387 8.06 27.0 -8.079
Dimethyl Sulfoxide 
0         
 50 1041 438 0.421 8.76 27.0 0.000
Test Chemical o-Anthranilic acid 
750         
 50 1033 554 0.536 11.08 27.0 27.464 
1000         
 50 1032 634 0.614 12.68 27.0 46.011 
1500         
 50 1011 777 0.769 15.54 27.0 82.661 
2000         
 0 0 0 0.000 0.00 27.0 N/A 
3000         
 0 0 0 0.000 0.00 27.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1041 1960 1.883 39.20 27.0 347.489
Trend: 10.570        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 11/21/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1042 398 0.382 7.96 27.0 -10.560
Dimethyl Sulfoxide 
0         
 50 1035 442 0.427 8.84 27.0 0.000
Test Chemical o-Anthranilic acid 
250         
 50 1037 435 0.419 8.70 27.0 -1.774 
500         
 50 1034 520 0.503 10.40 27.0 17.761 
1000         
 50 1041 644 0.619 12.88 27.0 44.862 
1500         
 50 1037 708 0.683 14.16 27.0 59.872 
1750         
 0 0 0 0.000 0.00 0.0 N/A 
2000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1037 2166 2.089 43.32 27.0 389.100
Trend: 10.078        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/23/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1028 412 0.401 8.24 27.0 8.284
Dimethyl Sulfoxide 
0         
 50 1024 379 0.370 7.58 27.0 0.000
Test Chemical o-Anthranilic acid 
50         
 50 1025 423 0.413 8.46 27.0 11.501 
160         
 50 1018 424 0.417 8.48 27.0 12.533 
500         
 50 1016 389 0.383 7.78 27.0 3.447 
1600         
 50 1027 424 0.413 8.48 27.0 11.547 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1026 1243 1.212 24.86 27.0 227.329
Trend: 0.898        
Probability: 0.185        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/06/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1041 437 0.420 8.74 26.5 5.405
Dimethyl Sulfoxide 
0         
 50 1037 413 0.398 8.26 26.5 0.000
Test Chemical o-Anthranilic acid 
1000         
 50 1026 438 0.427 8.76 26.5 7.190 
2000         
 50 1036 447 0.431 8.94 26.5 8.337 
3000         
 50 1035 605 0.585 12.10 26.5 46.772 
4000         
 50 1031 528 0.512 10.56 26.5 28.589
Positive Control Cyclophosphamide 
2         
 50 1038 2057 1.982 41.14 26.5 397.583
Trend: 5.779        
Probability: 0.000        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 11/21/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 411 0.396 8.22 26.0 0.000
Negative (Not Specified) 
0         
 50 1048 411 0.392 8.22 26.0 -0.859
Test Chemical o-Anthranilic acid 
1000         
 50 1039 420 0.404 8.40 26.0 2.190 
1500         
 50 1043 465 0.446 9.30 26.0 12.705 
2500         
 50 1032 523 0.507 10.46 26.0 28.114 
3500         
 50 1037 908 0.876 18.16 26.0 121.351
Positive Control Cyclophosphamide 
2         
 50 1046 1737 1.661 34.74 26.0 319.799
Trend: 14.614        
Probability: 0.000