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Study Information
Study Attribute Value
CEBS Accession Number: 002-03110-0002-0000-9
Chemical Name: o-Anthranilic acid
CASRN: 118-92-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 313261_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 11/02/1983    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0
Test Chemical: o-Anthranilic acid 
1000         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
1500         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
2000         
 100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0 
3000         
 100 8 0.080 8.0 1 0.010 1.0 7 0.070 7.0 0 0.000 0.0 
4000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 47 0.470 34.0 18 0.180 16.0 27 0.270 24.0 2 0.020 2.0
Trend: 1.819 -0.019 2.536  
Probability: 0.034 0.508 0.006  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/02/1983    Harvest Time: 10.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: o-Anthranilic acid 
1000         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
1500         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
2000         
 100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0 
3000         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 
4000         
 100 18 0.180 14.0 8 0.080 6.0 10 0.100 9.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 39 0.390 28.0 11 0.110 11.0 28 0.280 20.0 0 0.000 0.0
Trend: 3.531 2.829 2.841  
Probability: 0.000 0.002 0.002  


Trial #:2   Activation: No Activation    Date: 10/12/1983    Harvest Time: 10 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 0 0.000 0.0 2 0.020 2.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: o-Anthranilic acid 
50         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
160         
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0 
500         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
1600         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 
5000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 54 0.540 42.0 25 0.250 21.0 28 0.280 24.0 1 0.010 1.0
Trend: 1.484 0.718 1.448  
Probability: 0.069 0.236 0.074  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/12/1983    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: o-Anthranilic acid 
50         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
160         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
500         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
1600         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
5000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 56 0.560 40.0 33 0.330 27.0 23 0.230 18.0 0 0.000 0.0
Trend: -1.129 -0.707 -0.874  
Probability: 0.871 0.760 0.809