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Study Information
Study Attribute Value
CEBS Accession Number: 002-03110-0010-0000-8
Chemical Name: o-Anthranilic acid
CASRN: 118-92-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 919747_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/26/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 4.69 ± 0.268
Test Chemical o-Anthranilic acid 
150         
 4 4.79 ± 0.353
  
300         
 4 5.47 ± 0.501
  
600         
 3 7.51 ± 1.120
Positive Control Mitomycin-C 
 0.5       
 4 9.03 ± 0.821


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/10/87 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 4.74 ± 0.189
Test Chemical o-Anthranilic acid 
150         
 4 4.65 ± 0.509
  
300         
 4 4.27 ± 0.602
  
600         
 4 5.40 ± 0.250
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.06 ± 0.965


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 10/11/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 4.39 ± 0.575
Test Chemical o-Anthranilic acid 
150         
 4 3.81 ± 0.424
  
300         
 4 4.01 ± 0.741
  
600         
 3 6.62 ± 0.637
Positive Control Dimethylbenzanthracene 
2.5       
 4 11.43 ± 1.203


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed