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Study Information
Study Attribute Value
CEBS Accession Number: 002-03110-0011-0000-9
Chemical Name: o-Anthranilic acid
CASRN: 118-92-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 919747_CA
Study Result: Equivocal

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/21/85 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.2125
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 16.50 ± 1.72 0.0000
Test Chemical o-Anthranilic acid 
150         
 8 2.00 ± 0.76 0.3972
  
300         
 8 2.75 ± 0.53 0.1701
  
600         
 8 2.50 ± 0.73 0.2310
Vehicle Control No Stressor 
 0         
 8 1.75 ± 0.70 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/24/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0307
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 23.50 ± 2.03 0.0000
Test Chemical o-Anthranilic acid 
250         
 8 2.75 ± 0.84 0.0059
  
375         
 7 1.43 ± 0.57 0.0935
  
500         
 8 2.50 ± 0.91 0.0100
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/06/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0307
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 23.00 ± 6.01 0.0000
Test Chemical o-Anthranilic acid 
250         
 8 1.75 ± 0.96 0.1015
  
375         
 8 1.00 ± 0.53 0.3521
  
500         
 7 2.86 ± 0.96 0.0137
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed