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Study Information
Study Attribute Value
CEBS Accession Number: 002-03111-0001-0000-9
Chemical Name: o-Benzyl-p-chlorophenol
CASRN: 120-32-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 353016_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/01/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1036 438 0.423 8.76 26.5 -11.242
Dimethyl Sulfoxide 
0         
 50 1035 493 0.476 9.86 26.5 0.000
Test Chemical o-Benzyl-p-chlorophenol 
 0.5       
 50 1038 525 0.506 10.50 26.5 6.183 
1.6       
 50 1033 506 0.490 10.12 26.5 2.836 
5         
 50 1041 550 0.528 11.00 26.5 10.919 
16         
 50 1047 511 0.488 10.22 26.5 2.463
Positive Control Mitomycin-C 
 0.01      
 50 1043 1898 1.820 37.96 26.5 282.037
Trend: 0.658        
Probability: 0.255        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/01/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 507 0.486 10.14 26.0 -12.904
Dimethyl Sulfoxide 
0         
 50 1041 581 0.558 11.62 26.0 0.000
Test Chemical o-Benzyl-p-chlorophenol 
 0.05      
 50 1049 552 0.526 11.04 26.0 -5.716 
 0.16      
 50 1035 501 0.484 10.02 26.0 -13.269 
 0.5       
 50 1039 509 0.490 10.18 26.0 -12.224 
1.6       
 50 1046 501 0.479 10.02 26.0 -14.182 
5         
 50 1042 504 0.484 10.08 26.0 -13.336 
16         
 50 1044 554 0.531 11.08 26.0 -4.921
Positive Control Cyclophosphamide 
2         
 50 1047 3165 3.023 63.30 26.0 441.629
Trend: -1.480        
Probability: 0.931