COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-03111-0002-0000-0
Chemical Name: o-Benzyl-p-chlorophenol
CASRN: 120-32-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 353016_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/30/1982    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: o-Benzyl-p-chlorophenol
 0.16      
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
 0.5       
100 5 0.050 2.0 0 0.000 0.0 5 0.050 2.0 0 0.000 0.0
1.6       
100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
5         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
16         
100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.25      
100 21 0.210 20.0 6 0.060 5.0 10 0.100 10.0 5 0.050 5.0
Mitomycin-C
 0.5       
100 45 0.450 34.0 29 0.290 13.0 14 0.140 21.0 2 0.020 2.0
Trend: 0.627 0.886 -0.002  
Probability: 0.265 0.188 0.501  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/03/1982    Harvest Time: 14.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: o-Benzyl-p-chlorophenol
 0.5       
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
1.6       
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
5         
100 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 2 0.020 2.0
16         
100 4 0.040 3.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide
50         
100 120 1.200 60.0 35 0.350 26.0 39 0.390 28.0 46 0.460 23.0
Trend: 0.952 0.820 0.640  
Probability: 0.171 0.206 0.261  


Trial #:2   Activation: No Activation    Date: 03/30/1982    Harvest Time: 21 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: o-Benzyl-p-chlorophenol
 0.5       
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
1.6       
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
5         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
16         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.25      
100 8 0.080 8.0 4 0.040 4.0 4 0.040 4.0 0 0.000 0.0
Mitomycin-C
 0.5       
100 8 0.080 7.0 3 0.030 3.0 5 0.050 5.0 0 0.000 0.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 04/03/1982    Harvest Time: 18 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: o-Benzyl-p-chlorophenol
 0.5       
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
1.6       
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
5         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
16         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
50         
100 108 1.080 57.0 59 0.590 42.0 37 0.370 27.0 12 0.120 3.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000