Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03113-0012-0000-3 |
Chemical Name: | o-Chloroaniline |
CASRN: | 95-51-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 960448 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 103 | 99 | 163 | 53 | 52 |
107 | 86 | 160 | 50 | ||||
119 | 126 | 191 | 53 | ||||
111 | 89 | 179 | 54 | ||||
Test Chemical | o-Chloroaniline | 31.25 | 124r | 113 | 201 | 54 | |
112 | 93 | 165 | 49 | ||||
62.5 | 94 | 92 | 196 | 70 | 56 | ||
101 | 85 | 130 | 43 | ||||
125 | 117 | 97 | 249 | 71 | 65 | ||
104 | 96 | 180 | 58 | ||||
250 | 118 | 70 | 242 | 68 | |||
125r | 71 | 257 | 68 | ||||
500 | 109 | 31 | 226 | 69 | 67 | ||
110 | 36 | 213 | 65 | ||||
Positive Control | Methyl Methane Sulfonate | 15 | 39 | 19 | 378 | 322 | 314* |
42 | 19 | 382 | 306 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 60 | 84 | 55 | 31 | 28 |
83 | 119 | 77 | 31 | ||||
80 | 97 | 61 | 25 | ||||
97 | 100 | 74 | 25 | ||||
Test Chemical | o-Chloroaniline | 25 | 78 | 93 | 70 | 30 | 32 |
89 | 83 | 89 | 33 | ||||
50 | 94 | 95 | 104 | 37 | 32 | ||
77 | 76 | 65 | 28 | ||||
100 | 69 | 106 | 105 | 51 | 40 | ||
71 | 86 | 60 | 28 | ||||
200 | 78 | 71 | 79 | 34 | 38 | ||
71 | 70 | 92 | 43 | ||||
400 | 71 | 25 | 94 | 44 | 51* | ||
58 | 22 | 100 | 58 | ||||
Positive Control | Methyl Methane Sulfonate | 15 | 30 | 27 | 174 | 196 | 209* |
25 | 34 | 167 | 223 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 63 | 100 | 256 | 136 | 106 |
64 | 89 | 246 | 127 | ||||
86 | 114 | 187 | 73 | ||||
91 | 97 | 239 | 88 | ||||
Test Chemical | o-Chloroaniline | 200 | 44 | 41 | 182 | 139 | 141 |
51 | 47 | 217 | 143 | ||||
300 | 49 | 42 | 376 | 258 | 218* | ||
44 | 40 | 237 | 178 | ||||
400 | 58 | 38 | 519 | 300 | 310* | ||
57 | 40 | 551 | 320 | ||||
500 | 53# | 22 | 448.5 | 280 | 219* | ||
92 | 43 | 434 | 157 | ||||
600 | 86 | 39 | 425 | 166 | 187* | ||
71 | 24 | 445 | 209 | ||||
700 | |||||||
Positive Control | 3-Methylcholanthrene | 2.5 | 39 | 15 | 462 | 393 | 394* |
34 | 16 | 407 | 395 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 77 | 84 | 69 | 30 | 27 |
79 | 90 | 75 | 32 | ||||
81 | 125 | 46 | 19 | ||||
Test Chemical | o-Chloroaniline | 300 | 70 | 43 | 146 | 69 | 64* |
74 | 37 | 132 | 59 | ||||
400 | 72 | 36 | 278 | 128 | 139* | ||
82 | 33 | 370 | 150 | ||||
500 | 75 | 23 | 599 | 268 | 239* | ||
67 | 30 | 421 | 210 | ||||
600 | 71 | 16 | 818 | 382 | 336* | ||
71 | 19 | 616 | 291 | ||||
700 | 69 | 8 | 482 | 233 | 233* | ||
76 | 8 | 531 | 233 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 44 | 30 | 350 | 266 | 264* |
53 | 32 | 419 | 263 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination