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Study Information
Study Attribute Value
CEBS Accession Number: 002-03114-0002-0000-3
Chemical Name: o-Chlorobenzalmalononitrile (CS)
CASRN: 2698-41-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 171099_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 03/24/1983    Harvest Time: 19 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Acetone
0         
100 3 0.030 2.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: o-Chlorobenzalmalononitrile (CS)
6         
100 24 0.240 14.0 9 0.090 7.0 15 0.150 10.0 0 0.000 0.0
7         
100 40 0.400 27.0 26 0.260 21.0 14 0.140 10.0 0 0.000 0.0
9         
25 9 0.360 24.0 4 0.160 16.0 5 0.200 12.0 0 0.000 0.0
10         
100 26 0.260 20.0 13 0.130 11.0 13 0.130 11.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.065     
50 26 0.520 36.0 14 0.280 24.0 12 0.240 22.0 0 0.000 0.0
Trend: 3.537 2.388 2.304  
Probability: 0.000 0.008 0.011  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/24/1983    Harvest Time: 19 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Acetone
0         
100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: o-Chlorobenzalmalononitrile (CS)
20         
10 40 4.000 100.0 15 1.500 80.0 25 2.500 100.0 0 0.000 0.0
22.5       
10 59 5.900 100.0 15 1.500 80.0 24 2.400 70.0 20 2.000 20.0
25         
100 21 0.210 19.0 8 0.080 8.0 13 0.130 11.0 0 0.000 0.0
Positive Control: Cyclophosphamide
20         
25 13 0.520 28.0 7 0.280 20.0 6 0.240 16.0 0 0.000 0.0
Trend: 2.915 1.361 1.913  
Probability: 0.002 0.087 0.028