Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03114-0002-0000-3 |
Chemical Name: | o-Chlorobenzalmalononitrile (CS) |
CASRN: | 2698-41-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 171099_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Acetone | 0 | 100 | 3 | 0.030 | 2.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | o-Chlorobenzalmalononitrile (CS) | 6 | 100 | 24 | 0.240 | 14.0 | 9 | 0.090 | 7.0 | 15 | 0.150 | 10.0 | 0 | 0.000 | 0.0 |
7 | 100 | 40 | 0.400 | 27.0 | 26 | 0.260 | 21.0 | 14 | 0.140 | 10.0 | 0 | 0.000 | 0.0 | ||
9 | 25 | 9 | 0.360 | 24.0 | 4 | 0.160 | 16.0 | 5 | 0.200 | 12.0 | 0 | 0.000 | 0.0 | ||
10 | 100 | 26 | 0.260 | 20.0 | 13 | 0.130 | 11.0 | 13 | 0.130 | 11.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.065 | 50 | 26 | 0.520 | 36.0 | 14 | 0.280 | 24.0 | 12 | 0.240 | 22.0 | 0 | 0.000 | 0.0 |
Trend: | 3.537 | 2.388 | 2.304 | ||||||||||||
Probability: | 0.000 | 0.008 | 0.011 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Acetone | 0 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | o-Chlorobenzalmalononitrile (CS) | 20 | 10 | 40 | 4.000 | 100.0 | 15 | 1.500 | 80.0 | 25 | 2.500 | 100.0 | 0 | 0.000 | 0.0 |
22.5 | 10 | 59 | 5.900 | 100.0 | 15 | 1.500 | 80.0 | 24 | 2.400 | 70.0 | 20 | 2.000 | 20.0 | ||
25 | 100 | 21 | 0.210 | 19.0 | 8 | 0.080 | 8.0 | 13 | 0.130 | 11.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 20 | 25 | 13 | 0.520 | 28.0 | 7 | 0.280 | 20.0 | 6 | 0.240 | 16.0 | 0 | 0.000 | 0.0 |
Trend: | 2.915 | 1.361 | 1.913 | ||||||||||||
Probability: | 0.002 | 0.087 | 0.028 |