Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03114-0009-0000-0 |
Chemical Name: | o-Chlorobenzalmalononitrile (CS) |
CASRN: | 2698-41-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 668414 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 46r | 76 | 58.5 | 42 | 27 |
60 | 96 | 48 | 27 | ||||
68 | 104 | 56 | 28 | ||||
Test Chemical | o-Chlorobenzalmalononitrile (CS) | 0.3125 | 74 | 90 | 62 | 28 | 27 |
72 | 106 | 54 | 25 | ||||
0.625 | 168r | 231 | 52 | 10 | |||
68 | 94 | 174 | 85 | ||||
1.25 | 74 | 65 | 71 | 32 | 38 | ||
69 | 58 | 92 | 44 | ||||
2.5 | 65 | 32 | 153 | 78 | 75* | ||
70 | 31 | 150 | 71 | ||||
5 | |||||||
Positive Control | Ethyl Methane Sulfonate | 250 | 65 | 75 | 264 | 136 | 145* |
57 | 68 | 261 | 154 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 67 | 103 | 117 | 58 | 74 |
89 | 133 | 186 | 70 | ||||
59# | 92 | 192 | 108 | ||||
66 | 72 | 118 | 60 | ||||
Test Chemical | o-Chlorobenzalmalononitrile (CS) | 0.3125 | 76 | 104 | 182 | 80 | 79 |
69 | 87 | 160 | 78 | ||||
0.625 | 64 | 57 | 164 | 85 | 83 | ||
85 | 112 | 206 | 80 | ||||
1.25 | 74# | 71 | 180 | 81 | 81 | ||
72# | 71 | 177 | 82 | ||||
2.5 | 46 | 14 | 291 | 213 | 204* | ||
48 | 21 | 283 | 195 | ||||
5 | |||||||
Positive Control | Ethyl Methane Sulfonate | 250 | 58 | 68 | 323 | 187 | 239* |
55 | 72 | 478 | 291 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination