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Study Information
Study Attribute Value
CEBS Accession Number: 002-03129-0001-0000-8
Chemical Name: o-Nitroanisole
CASRN: 91-23-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 410303_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/14/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 461 0.441 9.22 26.0 0.000
Test Chemical o-Nitroanisole 
202         
 50 1043 541 0.519 10.82 32.5 17.691 
251         
 50 1028 565 0.550 11.30 32.5 24.706 
301         
 50 1042 567 0.544 11.34 32.5 23.466 
350         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1040 1922 1.848 38.44 26.0 319.325
Trend: 3.436        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 10/16/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1034 487 0.471 9.74 25.5 0.000
Test Chemical o-Nitroanisole 
12.3       
 50 1044 544 0.521 10.88 25.5 10.634 
41.2       
 50 1033 544 0.527 10.88 25.5 11.812 
123         
 50 1027 667 0.649 13.34 25.5 37.895
Positive Control Mitomycin-C 
 0.005     
 50 1046 1819 1.739 36.38 25.5 269.226
Trend: 5.230        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/14/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 388 0.376 7.76 25.5 0.000
Test Chemical o-Nitroanisole 
608         
 50 1033 516 0.500 10.32 25.5 32.990 
811         
 50 1023 540 0.528 10.80 25.5 40.536 
1010         
 50 1026 543 0.529 10.86 32.0 40.903
Positive Control Cyclophosphamide 
1.5       
 50 1040 1860 1.788 37.20 25.5 376.155
Trend: 5.104        
Probability: 0.000