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Study Information
Study Attribute Value
CEBS Accession Number: 002-03129-0002-0000-9
Chemical Name: o-Nitroanisole
CASRN: 91-23-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 410303_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Negative 

Trial #:1   Activation: No Activation    Date: 11/05/1981    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: o-Nitroanisole 
655.1       
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
722.7       
 50 1 0.020 2.0 0 0.000 0.0 1 0.020 2.0 0 0.000 0.0 
803.4       
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 21 0.210 17.0 13 0.130 13.0 7 0.070 7.0 1 0.010 1.0
Trend: 0.342 -1.212 1.277  
Probability: 0.366 0.887 0.101  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/15/1981    Harvest Time: 11 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 6 0.060 5.0 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0
Test Chemical: o-Nitroanisole 
519         
 100 5 0.050 5.0 4 0.040 4.0 1 0.010 1.0 0 0.000 0.0 
742         
 100 12 0.120 11.0 3 0.030 3.0 9 0.090 9.0 0 0.000 0.0 
1060         
 100 55 0.550 49.0 4 0.040 2.0 51 0.510 49.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 33 0.330 26.0 21 0.210 18.0 12 0.120 12.0 0 0.000 0.0
Trend: 8.119 -0.524 9.266  
Probability: 0.000 0.700 0.000  


Trial #:2   Activation: No Activation    Date: 10/15/1981    Harvest Time: 11 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: o-Nitroanisole 
216.3       
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
432.6       
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0 
618         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 30 0.300 23.0 20 0.200 19.0 10 0.100 10.0 0 0.000 0.0
Trend: 0.000 -0.183 0.000  
Probability: 0.500 0.572 0.000