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Study Information
Study Attribute Value
CEBS Accession Number: 002-03131-0002-0000-2
Chemical Name: o-Nitrobenzoic acid
CASRN: 552-16-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 778268_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/20/1985    Harvest Time: 21.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 7 0.035 2.5 2 0.010 1.0 5 0.025 1.5 0 0.000 0.0
Test Chemical: o-Nitrobenzoic acid 
3000         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
3975         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
5000         
 200 5 0.025 2.0 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 25 16 0.640 48.0 6 0.240 20.0 10 0.400 36.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 19 0.760 44.0 13 0.520 36.0 6 0.240 20.0 0 0.000 0.0
Trend: -0.155 -0.807 0.734  
Probability: 0.562 0.790 0.231  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/23/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 3 0.015 1.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: o-Nitrobenzoic acid 
3000         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
3975         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
5000         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 42 0.210 15.5 21 0.105 9.0 21 0.105 8.5 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 19 0.760 44.0 11 0.440 36.0 8 0.320 20.0 0 0.000 0.0
Trend: -0.650 -0.831 -0.055  
Probability: 0.742 0.797 0.522