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Study Information
Study Attribute Value
CEBS Accession Number: 002-03136-0002-0000-7
Chemical Name: o-Phenanthroline
CASRN: 66-71-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 864285_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Questionable 

Trial #:1   Activation: No Activation    Date: 08/10/1983    Harvest Time: 22 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: o-Phenanthroline 
 0.2       
 82 5 0.061 2.4 1 0.012 1.2 4 0.049 2.4 0 0.000 0.0 
 0.225     
 64 3 0.047 3.1 1 0.016 1.6 2 0.031 1.6 0 0.000 0.0 
 0.25      
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.08      
 50 42 0.840 50.0 23 0.460 32.0 18 0.360 22.0 1 0.020 2.0
Trend: 0.443 1.157 0.372  
Probability: 0.329 0.124 0.355  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/10/1983    Harvest Time: 22 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 7 0.070 6.0 5 0.050 5.0 1 0.010 1.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 6 0.060 6.0 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0
Test Chemical: o-Phenanthroline 
60         
 100 14 0.140 11.0 6 0.060 4.0 7 0.070 7.0 1 0.010 1.0 
65         
 100 39 0.390 25.0 27 0.270 20.0 12 0.120 11.0 0 0.000 0.0 
70         
 100 31 0.310 15.0 19 0.190 9.0 8 0.080 5.0 4 0.040 4.0
Positive Control: Cyclophosphamide 
17.5       
 25 23 0.920 60.0 17 0.680 52.0 6 0.240 20.0 0 0.000 0.0
Trend: 2.665 2.712 1.537  
Probability: 0.004 0.003 0.062  


Trial #:2   Activation: No Activation    Date: 08/23/1983    Harvest Time: 22 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: o-Phenanthroline 
 0.225     
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
 0.25      
 100 8 0.080 7.0 2 0.020 2.0 3 0.030 3.0 3 0.030 3.0 
 0.275     
 100 5 0.050 5.0 1 0.010 1.0 2 0.020 2.0 2 0.020 2.0 
 0.3       
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 50 29 0.580 42.0 14 0.280 24.0 15 0.300 24.0 0 0.000 0.0
Trend: 1.469 0.661 1.042  
Probability: 0.071 0.254 0.149