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Study Information
Study Attribute Value
CEBS Accession Number: 002-03139-0001-0000-9
Chemical Name: o-Phenylphenol
CASRN: 90-43-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 913440_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/15/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 445 0.433 8.90 25.5 0.000
Test Chemical o-Phenylphenol 
1.7       
 50 1021 444 0.435 8.88 25.5 0.459 
5         
 50 1023 473 0.462 9.46 25.5 6.812 
16.7       
 50 1033 617 0.597 12.34 34.3 37.981 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1032 758 0.734 15.16 25.5 69.677
Mitomycin-C 
 0.01      
 5 103 194 1.883 38.80 25.5 335.109
Trend: 5.447        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/24/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1035 437 0.422 8.74 25.5 0.000
Test Chemical o-Phenylphenol 
14.9       
 50 1025 481 0.469 9.62 31.2 11.142 
20         
 50 1031 513 0.498 10.26 31.2 17.847 
29.9       
 50 1042 567 0.544 11.34 37.0 28.877 
40.1       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1027 657 0.640 13.14 25.5 51.514
Mitomycin-C 
 0.01      
 5 102 135 1.324 27.00 25.5 213.467
Trend: 4.091        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/24/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1025 443 0.432 8.86 25.5 0.000
Test Chemical o-Phenylphenol 
24.9       
 50 1017 480 0.472 9.60 25.5 9.204 
49.8       
 50 1019 488 0.479 9.76 25.5 10.807 
75.4       
 50 1034 530 0.513 10.60 31.2 18.597 
100.5       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1033 667 0.646 13.34 25.5 49.398
Cyclophosphamide 
2         
 5 104 171 1.644 34.20 25.5 280.437
Trend: 2.519        
Probability: 0.006