Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-03139-0008-0000-6
Chemical Name:	o-Phenylphenol
CASRN:	90-43-7
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	550257
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	124r	93	100	27	28
			97	85	97	33
			108	115	74	23
			123r	94	110	30
Test Chemical	o-Phenylphenol	5	100	83	83	28	34
			134r	71	116	29
			83	58	101	41
		10	103	51	118	38	34
			135r	67	121	30
			111	56	100	30
		20	104#	46	96	31	40
			91	36	144	53
			97	37	102	35
		30	120#	28	109	30	49*
			99	22	174	59
			90	22	159	59
		40	91	11	117	43	72*
			79	11	191	81
			75	10	210	93
Positive Control	Methyl Methane Sulfonate	5	82	44	669	271	297*
			71	36	656	310
			76	32	707	309

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	115	112	85	25	29
			119	135	89	25
			95	79	103	36
			113	74	101	30
Test Chemical	o-Phenylphenol	5	90#	90	54	20	44
			90#	91	73.5	27
			32#	37	80	84
		10	119	93	77	22	23
			105	78	79	25
			109#	80	76	23
		20	95	42	66	23	24
			83#	48	67	27
			99	40	61	21
		30	95	22	92	32	33
			118	30	87	25
			113	32	141	42
		40	92	18	168	61	65*
			84	14	192	76
			103#	12	179	58
		50	60	4	213	119	104*
			76	9	166	72
			69	6	248	120
Positive Control	Methyl Methane Sulfonate	5	109	67	466	143	188*
			72	64	460	213
			76	45	476	208

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination