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Study Information
Study Attribute Value
CEBS Accession Number: 002-03139-0008-0000-6
Chemical Name: o-Phenylphenol
CASRN: 90-43-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 550257
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 124r 93 100 27 28
    97 85 97 33
    108 115 74 23
    123r 94 110 30
Test Chemical o-Phenylphenol 
5         
 100 83 83 28 34
    134r 71 116 29
    83 58 101 41
  
10         
 103 51 118 38 34
    135r 67 121 30
    111 56 100 30
  
20         
 104# 46 96 31 40
    91 36 144 53
    97 37 102 35
  
30         
 120# 28 109 30 49*
    99 22 174 59
    90 22 159 59
  
40         
 91 11 117 43 72*
    79 11 191 81
    75 10 210 93
Positive Control Methyl Methane Sulfonate 
5         
 82 44 669 271 297*
    71 36 656 310
    76 32 707 309

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 115 112 85 25 29
    119 135 89 25
    95 79 103 36
    113 74 101 30
Test Chemical o-Phenylphenol 
5         
 90# 90 54 20 44
    90# 91 73.5 27
    32# 37 80 84
  
10         
 119 93 77 22 23
    105 78 79 25
    109# 80 76 23
  
20         
 95 42 66 23 24
    83# 48 67 27
    99 40 61 21
  
30         
 95 22 92 32 33
    118 30 87 25
    113 32 141 42
  
40         
 92 18 168 61 65*
    84 14 192 76
    103# 12 179 58
  
50         
 60 4 213 119 104*
    76 9 166 72
    69 6 248 120
Positive Control Methyl Methane Sulfonate 
5         
 109 67 466 143 188*
    72 64 460 213
    76 45 476 208

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination