Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03143-0002-0000-5 |
Chemical Name: | o-Toluidine hydrochloride |
CASRN: | 636-21-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 867721_CA |
Study Result: | Equivocal |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | o-Toluidine hydrochloride | 160 | 100 | 9 | 0.090 | 9.0 | 3 | 0.030 | 3.0 | 6 | 0.060 | 6.0 | 0 | 0.000 | 0.0 |
500 | 100 | 8 | 0.080 | 8.0 | 1 | 0.010 | 1.0 | 7 | 0.070 | 7.0 | 0 | 0.000 | 0.0 | ||
1600 | 100 | 12 | 0.120 | 10.0 | 2 | 0.020 | 2.0 | 10 | 0.100 | 8.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.15 | 50 | 15 | 0.300 | 22.0 | 8 | 0.160 | 14.0 | 7 | 0.140 | 12.0 | 0 | 0.000 | 0.0 |
Trend: | 1.984 | 0.173 | 2.157 | ||||||||||||
Probability: | 0.024 | 0.431 | 0.016 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 5 | 0.050 | 5.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
Test Chemical: | o-Toluidine hydrochloride | 160 | 100 | 6 | 0.060 | 5.0 | 1 | 0.010 | 1.0 | 5 | 0.050 | 4.0 | 0 | 0.000 | 0.0 |
500 | 100 | 5 | 0.050 | 5.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
1600 | 100 | 6 | 0.060 | 6.0 | 2 | 0.020 | 2.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 50 | 21 | 0.420 | 24.0 | 4 | 0.080 | 8.0 | 17 | 0.340 | 18.0 | 0 | 0.000 | 0.0 |
Trend: | 0.302 | 0.605 | 0.000 | ||||||||||||
Probability: | 0.381 | 0.272 | 0.500 |