Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-03147-0011-0000-9
Chemical Name: p,p'-Dichlorodiphenyl dichloroethylene
CASRN: 72-55-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 202120
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 84 104 107 43 47
    84 96 111 44
    69 85 104 50
    81 115 119 49
Test Chemical p,p'-Dichlorodiphenyl dichloroethylene 
3.125     
 84 106 101 40 39
    71 73 80 37
  
6.25      
 57 74 104 60 59
    86 108 149 58
  
12.5       
 75 82 126 56 70
    50 67 127 85
  
25         
 47 40 100 71 74*
    64 63 150 78
  
50         
 39 9 257 220 224*
    50 7 340 228
  
100         
   
Positive Control Methyl Methane Sulfonate 
15         
 31 20 170 185 192*
    26 19 155 199

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 103 99 170 55 56
    87 114 154 59
    84 90 117 46
    82 96 157 64
Test Chemical p,p'-Dichlorodiphenyl dichloroethylene 
25         
 74 59 132 60 64
    77 63 157 68
  
30         
 87 42 254 97 90*
    107 47 265 83
  
35         
 80 27 285 119 120*
    89 24 324 121
  
40         
 69# 12 354 171
  
45         
 39 5 460 391 496*
    37 5 664 601
Positive Control Methyl Methane Sulfonate 
15         
 55 28 419 255 263*
    41 37 333 271

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination