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Study Information
Study Attribute Value
CEBS Accession Number: 002-03148-0002-0000-0
Chemical Name: p,p'-Dichlorodiphenyl sulfone
CASRN: 80-07-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 133717_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/19/1991    Harvest Time: 15.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: p,p'-Dichlorodiphenyl sulfone 
94         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
201         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
432         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 28 1.120 48.0 13 0.520 36.0 5 0.200 16.0 10 0.400 4.0
Trend: 1.404 0.635 1.292  
Probability: 0.080 0.263 0.098  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/21/1991    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: p,p'-Dichlorodiphenyl sulfone 
9.4       
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
20         
 200 7 0.035 0.5 0 0.000 0.0 7 0.035 0.5 0 0.000 0.0 
930         
 200 12 0.060 3.5 2 0.010 1.0 10 0.050 3.0 0 0.000 0.0 
2000         
 200 11 0.055 1.0 0 0.000 0.0 1 0.005 0.5 10 0.050 0.5
Positive Control: Cyclophosphamide 
20         
 25 35 1.400 48.0 13 0.520 36.0 2 0.080 8.0 20 0.800 8.0
Trend: 2.986 1.449 2.509  
Probability: 0.001 0.074 0.006  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 08/22/1991    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 200 4 0.020 2.0 4 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: p,p'-Dichlorodiphenyl sulfone 
750         
 200 4 0.020 2.0 4 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
1000         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
1250         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
1500         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
2000         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 11 0.440 36.0 3 0.120 12.0 8 0.320 24.0 0 0.000 0.0
Trend: 0.548 -0.853 2.565  
Probability: 0.292 0.803 0.005