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Study Information
Study Attribute Value
CEBS Accession Number: 002-03157-0001-0000-9
Chemical Name: p-Benzoquinone dioxime
CASRN: 105-11-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 233313_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 
Induced Rat Liver S9  3_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/13/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 387 0.370 7.74 26.0 8.799
Dimethyl Sulfoxide 
0         
 50 1041 354 0.340 7.08 26.0 0.000
Test Chemical p-Benzoquinone dioxime 
 0.5       
 50 1045 441 0.422 8.82 26.0 24.099 
1.6       
 50 1036 434 0.419 8.68 26.0 23.191 
5         
 50 1045 497 0.476 9.94 26.0 39.858 
16         
 0 0 0 0.000 0.00 26.0 N/A 
50         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.003     
 50 1041 1023 0.983 20.46 26.0 188.983
Mitomycin-C 
 0.005     
 50 1037 1248 1.203 24.96 26.0 253.902
Trend: 4.524        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/25/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1033 386 0.374 7.72 27.0 8.838
Dimethyl Sulfoxide 
0         
 50 1034 355 0.343 7.10 27.0 0.000
Test Chemical p-Benzoquinone dioxime 
1         
 50 1042 455 0.437 9.10 31.0 27.185 
2         
 50 1043 518 0.497 10.36 31.0 44.656 
5         
 50 1042 585 0.561 11.70 31.0 63.524 
10         
 0 0 0 0.000 0.00 31.0 N/A 
20         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.003     
 50 1039 1241 1.194 24.82 27.0 247.895
Trend: 7.557        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/13/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1034 335 0.324 6.70 26.0 -8.687
Dimethyl Sulfoxide 
0         
 50 1040 369 0.355 7.38 26.0 0.000
Test Chemical p-Benzoquinone dioxime 
5         
 50 1044 421 0.403 8.42 50.0 13.655 
16         
 50 1035 414 0.400 8.28 50.0 12.737 
50         
 50 1048 418 0.399 8.36 50.0 12.414 
160         
 50 1041 464 0.446 9.28 50.0 25.624 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1030 1071 1.040 21.42 26.0 193.062
Trend: 2.859        
Probability: 0.002        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/25/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 382 0.370 7.64 27.0 0.000
Negative (Not Specified) 
0         
 50 1038 415 0.400 8.30 27.0 8.115
Test Chemical p-Benzoquinone dioxime 
50         
 50 1045 465 0.445 9.30 30.0 20.330 
100         
 50 1040 548 0.527 10.96 30.0 42.490 
200         
 50 1036 682 0.658 13.64 30.0 78.017 
300         
 50 1040 1092 1.050 21.84 30.0 183.940 
500         
 0 0 0 0.000 0.00 30.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1041 1185 1.138 23.70 27.0 207.825
Trend: 19.891        
Probability: 0.000        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 05/25/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1038 415 0.400 8.30 27.0 8.115
Dimethyl Sulfoxide 
0         
 50 1033 382 0.370 7.64 27.0 0.000
Test Chemical p-Benzoquinone dioxime 
200         
 0 0 0 0.000 0.00 42.0 N/A 
300         
 50 1039 961 0.925 19.22 42.0 150.118 
400         
 50 1022 1021 0.999 20.42 42.0 170.154 
500         
 50 1047 1163 1.111 23.26 42.0 200.379
Positive Control Cyclophosphamide 
1.5       
 50 1041 1185 1.138 23.70 27.0 207.825
Trend: 19.596        
Probability: 0.000