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Study Information
Study Attribute Value
CEBS Accession Number: 002-03157-0002-0000-0
Chemical Name: p-Benzoquinone dioxime
CASRN: 105-11-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 233313_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Weakly Positive* 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 05/10/1983    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: p-Benzoquinone dioxime 
2         
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
5         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
10         
 100 47 0.470 28.0 21 0.210 20.0 25 0.250 15.0 1 0.010 1.0 
10         
 100 12 0.120 8.0 8 0.080 5.0 4 0.040 4.0 0 0.000 0.0 
20         
 100 14 0.140 10.0 9 0.090 7.0 5 0.050 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 22 0.220 21.0 13 0.130 13.0 9 0.090 9.0 0 0.000 0.0
Trend: 4.602 4.008 3.158  
Probability: 0.000 0.000 0.001  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/10/1983    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: p-Benzoquinone dioxime 
100         
 100 22 0.220 14.0 18 0.180 12.0 4 0.040 4.0 0 0.000 0.0 
200         
 100 97 0.970 52.0 75 0.750 46.0 22 0.220 17.0 0 0.000 0.0 
300         
 100 137 1.370 68.0 105 1.050 57.0 32 0.320 26.0 0 0.000 0.0 
400         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 15 0.150 14.0 6 0.060 6.0 9 0.090 9.0 0 0.000 0.0
Trend: 11.323 9.977 6.381  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 04/19/1983    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: p-Benzoquinone dioxime 
 0.5       
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
1.6       
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
5         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
16         
 100 90 0.900 45.0 30 0.300 21.0 53 0.530 29.0 7 0.070 7.0 
50         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 109 1.090 60.0 59 0.590 42.0 50 0.500 38.0 0 0.000 0.0
Trend: 8.395 5.953 6.451  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 04/19/1983    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: p-Benzoquinone dioxime 
16         
 100 5 0.050 4.0 1 0.010 1.0 4 0.040 3.0 0 0.000 0.0 
50         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
160         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
500         
 100 85 0.850 54.0 43 0.430 35.0 42 0.420 31.0 0 0.000 0.0 
1600         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 31 0.310 26.0 11 0.110 9.0 20 0.200 18.0 0 0.000 0.0
Trend: 9.775 8.326 6.877  
Probability: 0.000 0.000 0.000