Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-03157-0010-0000-9
Chemical Name:	p-Benzoquinone dioxime
CASRN:	105-11-3
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	034164
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	80	99	55	23	22
			78	106	46	20
			85	91	51	20
			83	103	60	24
Test Chemical	p-Benzoquinone dioxime	6.25	86	100	51	20	20
			83	104	51	21	20
		12.5	93	90	84	30	27
			69	88	51	25	27
		25	61	59	71	39	39*
			83	74	96	39	39*
		50	52	20	144	91	90*
			52	24	140	89	90*
		100

Positive Control	Methyl Methane Sulfonate	15	47	36	122	86	75*
			50	41	95	64	75*
	Methyl Methane Sulfonate	250	83	114	281	112	116*
			90	132	324	120	116*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	63	105	36	19	22
			60	95	44	25
			42r	70	40	32
			41r	59	83	67
Test Chemical	p-Benzoquinone dioxime	6.25	71	113	75	35	28
			68	118	43	21	28
		12.5	74	106	57	26	23
			73	111	44	20	23
		25	75	87	56	25	32
			60	71	70	39	32
		50	53	26	121	76	86*
			52	25	149	96	86*
		75	33	5	369	373	421*
			25	4	347	469	421*
		100

Positive Control	Methyl Methane Sulfonate	15	34	35	84	82	83*
			32	35	81	85	83*
	Methyl Methane Sulfonate	250	80	108	442	183	186*
			79	105	449	189	186*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination