COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-03161-0001-0000-4
Chemical Name: p-Chloroaniline
CASRN: 106-47-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 096094_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/01/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 449 0.428 8.98 25.5 0.000
Test Chemical p-Chloroaniline 
16.7       
 50 1039 589 0.567 11.78 25.5 32.317 
50         
 50 1043 586 0.562 11.72 25.5 31.138 
167         
 50 1044 773 0.740 15.46 33.5 72.820 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 692 0.659 13.84 25.5 53.827
Mitomycin-C 
 0.01      
 5 105 259 2.467 51.80 25.5 475.739
Trend: 8.935        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 12/15/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 497 0.475 9.94 25.8 0.000
Test Chemical p-Chloroaniline 
150         
 50 1050 769 0.732 15.38 35.3 54.139 
175         
 50 1043 736 0.706 14.72 35.3 48.514 
200         
 50 1047 843 0.805 16.86 35.3 69.456
Positive Control Mitomycin-C 
 0.001     
 50 1049 695 0.663 13.90 25.8 39.439
Mitomycin-C 
 0.01      
 5 105 302 2.876 60.40 25.8 505.331
Trend: 8.419        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/01/1982    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 452 0.433 9.04 25.5 0.000
Test Chemical p-Chloroaniline 
500         
 50 1048 451 0.430 9.02 25.5 -0.602 
1670         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.35      
 50 1046 704 0.673 14.08 25.5 55.454
Cyclophosphamide 
2         
 5 104 139 1.337 27.80 25.5 208.705
Trend: -0.091        
Probability: 0.536        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/15/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 478 0.456 9.56 25.8 0.000
Test Chemical p-Chloroaniline 
900         
 50 1043 656 0.629 13.12 25.8 37.896 
1000         
 50 1036 823 0.794 16.46 35.3 74.170 
1100         
 50 1043 794 0.761 15.88 35.3 66.905 
1200         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.35      
 50 1046 725 0.693 14.50 25.8 51.964
Cyclophosphamide 
2         
 5 104 210 2.019 42.00 25.8 342.710
Trend: 9.656        
Probability: 0.000