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Study Information
Study Attribute Value
CEBS Accession Number: 002-03161-0002-0000-5
Chemical Name: p-Chloroaniline
CASRN: 106-47-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 096094_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 01/04/1983    Harvest Time: 23 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 7 0.070 4.0 2 0.020 2.0 5 0.050 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 3 0.030 3.0 0 0.000 0.0 1 0.010 1.0
Test Chemical: p-Chloroaniline 
400         
 100 19 0.190 10.0 0 0.000 0.0 8 0.080 8.0 11 0.110 2.0 
450         
 100 8 0.080 7.0 3 0.030 3.0 4 0.040 4.0 1 0.010 1.0 
500         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
600         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.062     
 50 52 1.040 58.0 27 0.540 40.0 25 0.500 36.0 0 0.000 0.0
Trend: -0.438 -0.540 0.054  
Probability: 0.669 0.705 0.479  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/04/1983    Harvest Time: 23 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 1 0.010 1.0 2 0.020 2.0
Test Chemical: p-Chloroaniline 
800         
 100 5 0.050 5.0 2 0.020 2.0 2 0.020 2.0 1 0.010 1.0 
900         
 100 27 0.270 21.0 14 0.140 11.0 13 0.130 11.0 0 0.000 0.0 
1000         
 50 35 0.700 38.0 13 0.260 20.0 22 0.440 32.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
10         
 50 19 0.380 24.0 6 0.120 12.0 11 0.220 18.0 2 0.040 2.0
Trend: 6.122 4.747 6.154  
Probability: 0.000 0.000 0.000