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Study Information
Study Attribute Value
CEBS Accession Number: 002-03165-0001-0000-8
Chemical Name: p-Cresidine
CASRN: 120-71-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 459789_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Negative 
Induced Rat Liver S9  3_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 12/30/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 395 0.380 7.90 26.0 0.000
Test Chemical p-Cresidine 
 0.5       
 50 1039 454 0.437 9.08 26.0 15.047 
1.6       
 50 1047 463 0.442 9.26 26.0 16.432 
16         
 50 1045 436 0.417 8.72 26.0 9.852 
50         
 50 1041 428 0.411 8.56 26.0 8.250 
160         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1047 556 0.531 11.12 26.0 39.818
Mitomycin-C 
 0.005     
 10 210 292 1.390 29.20 26.0 266.100
Trend: 0.535        
Probability: 0.296        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/30/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 409 0.390 8.18 26.0 0.000
Test Chemical p-Cresidine 
50         
 50 1039 472 0.454 9.44 26.0 16.403 
160         
 50 1044 409 0.392 8.18 26.0 0.383 
500         
 50 1043 457 0.438 9.14 26.0 12.272 
1600         
 50 1044 500 0.479 10.00 26.0 22.718
Positive Control Cyclophosphamide 
 0.1       
 50 1043 558 0.535 11.16 26.0 37.084
Cyclophosphamide 
 0.6       
 10 209 198 0.947 19.80 26.0 142.749
Trend: 2.512        
Probability: 0.006        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/08/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 446 0.425 8.92 26.0 0.000
Test Chemical p-Cresidine 
16         
 50 1050 471 0.449 9.42 26.0 5.605 
50         
 50 1047 413 0.394 8.26 26.0 -7.134 
160         
 50 1049 456 0.435 9.12 26.0 2.340 
500         
 50 1050 497 0.473 9.94 26.0 11.435
Positive Control Cyclophosphamide 
 0.15      
 50 1051 561 0.534 11.22 26.0 25.665
Cyclophosphamide 
 0.6       
 10 211 237 1.123 23.70 26.0 164.436
Trend: 1.297        
Probability: 0.097        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 12/13/1988    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 419 0.400 8.38 26.0 0.000
Test Chemical p-Cresidine 
500         
 50 1047 452 0.432 9.04 26.0 7.876 
750         
 50 1046 416 0.398 8.32 26.0 -0.621 
1000         
 50 1047 400 0.382 8.00 26.0 -4.535 
1250         
 50 1048 511 0.488 10.22 26.0 21.841
Positive Control Cyclophosphamide 
 0.15      
 50 1044 499 0.478 9.98 26.0 19.435
Cyclophosphamide 
 0.6       
 10 207 182 0.879 18.20 26.0 119.702
Trend: 1.650        
Probability: 0.049