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Study Information
Study Attribute Value
CEBS Accession Number: 002-03165-0002-0000-9
Chemical Name: p-Cresidine
CASRN: 120-71-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 459789_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 03/12/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: p-Cresidine 
300         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
500         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
1000         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 45 0.225 20.0 13 0.065 6.5 32 0.160 14.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 19 0.380 34.0 4 0.080 8.0 15 0.300 28.0 0 0.000 0.0
Trend: 0.869 -0.419 1.087  
Probability: 0.192 0.662 0.138  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/12/1987    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: p-Cresidine 
300         
 200 2 0.010 0.5 0 0.000 0.0 2 0.010 0.5 0 0.000 0.0 
500         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
1000         
 200 12 0.060 6.0 3 0.015 1.5 9 0.045 4.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 46 0.230 20.0 12 0.060 6.0 34 0.170 16.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 21 0.420 38.0 7 0.140 14.0 14 0.280 26.0 0 0.000 0.0
Trend: 3.932 2.420 3.197  
Probability: 0.000 0.008 0.001  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 04/29/1987    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: p-Cresidine 
300         
 200 5 0.025 1.5 0 0.000 0.0 5 0.025 1.5 0 0.000 0.0 
500         
 200 6 0.030 2.0 3 0.015 0.5 3 0.015 1.5 0 0.000 0.0 
1000         
 200 17 0.085 7.0 5 0.025 2.0 12 0.060 5.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 35 0.175 15.0 8 0.040 4.0 27 0.135 11.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 33 0.660 36.0 9 0.180 12.0 24 0.480 32.0 0 0.000 0.0
Trend: 3.600 2.659 2.643  
Probability: 0.000 0.004 0.004