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Study Information
Study Attribute Value
CEBS Accession Number: 002-03169-0001-0000-2
Chemical Name: p-Isopropoxydiphenylamine
CASRN: 101-73-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 843024_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Negative 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/11/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 385 0.367 7.70 26.5 0.000
Test Chemical p-Isopropoxydiphenylamine 
 0.965     
 50 1043 485 0.465 9.70 26.5 26.699 
2.9       
 50 1035 523 0.505 10.46 26.5 37.682 
9.65      
 50 1043 601 0.576 12.02 26.5 57.002 
29         
 0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1040 559 0.538 11.18 26.5 46.451
Mitomycin-C 
 0.01      
 10 206 206 1.000 20.60 26.5 172.468
Trend: 6.987        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/11/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 513 0.493 10.26 26.5 0.000
Negative (Not Specified) 
0         
 50 1049 442 0.421 8.84 26.5 -14.497
Test Chemical p-Isopropoxydiphenylamine 
 0.995     
 50 1027 475 0.463 9.50 26.5 -6.145 
4.99      
 50 1035 516 0.499 10.32 26.5 1.168 
9.95      
 50 1037 584 0.563 11.68 26.5 14.279 
15         
 0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1041 995 0.956 19.90 26.5 93.957
Mitomycin-C 
 0.01      
 10 211 392 1.858 39.20 26.5 276.996
Trend: 2.437        
Probability: 0.007        

Trial #: 3    Activation: No Activation    Date: 04/08/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1026 404 0.394 8.08 26.5 0.000
Test Chemical p-Isopropoxydiphenylamine 
4.97      
 50 1032 530 0.514 10.60 26.5 30.425 
7.45      
 50 1027 510 0.497 10.20 26.5 26.115 
9.95      
 50 1026 485 0.473 9.70 26.5 20.050 
14.9       
 8 167 83 0.497 10.38 26.5 26.220
Positive Control Mitomycin-C 
 0.002     
 100 2055 1043 0.508 10.43 26.5 28.896
Mitomycin-C 
 0.01      
 10 206 212 1.029 21.20 26.5 161.357
Trend: 2.390        
Probability: 0.008        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/11/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 463 0.444 9.26 25.5 0.000
Test Chemical p-Isopropoxydiphenylamine 
2.9       
 50 1029 474 0.461 9.48 25.5 3.669 
9.65      
 50 1030 463 0.450 9.26 25.5 1.165 
29         
 50 1029 658 0.639 13.16 25.5 43.912 
96.5       
 0 0 0 0.000 0.00 29.5 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1024 619 0.604 12.38 25.5 36.043
Cyclophosphamide 
2.5       
 10 206 221 1.073 22.10 25.5 141.441
Trend: 5.759        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 04/07/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1016 445 0.438 8.90 26.0 0.000
Test Chemical p-Isopropoxydiphenylamine 
19.9       
 50 1028 572 0.556 11.44 26.0 27.039 
24.9       
 50 1017 551 0.542 11.02 26.0 23.698 
29.8       
 50 1032 636 0.616 12.72 26.0 40.706 
49.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1036 662 0.639 13.24 26.0 45.892
Cyclophosphamide 
2.5       
 10 210 240 1.143 24.00 26.0 160.931
Trend: 5.178        
Probability: 0.000